RNA interference (RNAi): by Nature Video

RNA interference (RNAi): by Nature Video

scientists have been making rapid progress in understanding RNA interference or RNAi AI many organisms use RNAi eye to control genes and it can also be used as a tool in the laboratory and in the future perhaps as a therapy this animation will introduce you to the principles of RNAi I involving two important types of RNA molecule small interfering RNAs and micro RNAs eukaryotic cells have many sophisticated ways of controlling gene expression in the complex environment of a cell these mechanisms need to be precisely targeted there’s a group of mechanisms that use small RNA molecules to direct gene silencing this is called RNAi I inside the nucleus most genes that encode proteins are transcribed by RNA polymerase 2 the primary RNA transcript is processed by splicing and forms a mature messenger RNA sometimes called mRNA the messenger RNA is then exported from the nucleus into the cytoplasm here ribosomes catalyze translation of the messenger RNA to form polypeptide chains that fold into proteins but this is also where some small RNA molecules can have their silencing effects there are several types of regulatory small RNA small interfering RNAs known as SI rnas are derived from longer double-stranded RNAs that are either produced in the cell itself or are delivered into cells experimentally the introduction of si RNAs or double stranded RNA is widely used to manipulate gene expression micro RNAs are another type of small RNA most micro RNAs come from RNAs that are transcribed in the nucleus which then fold and a processed before being exported into the cytoplasm as double stranded precursor micro RNAs the double-stranded precursors of micro rnas and si RNAs bind to Dicer which is an endonuclease protein that cuts the RNA into short segments most si RNAs and micro rnas are approximately 21 nucleotides long the short double-stranded RNA then binds an Argonaut protein one strand of the RNA is selected and remained bound to Argonaut this is called the guide strand the combination of the RNA and Argonaut along with other proteins is called the RNA induced silencing complex or risk Si RNAs direct risk to bind to specific messenger RNAs the targeting is precise because it’s determined by base pairing between the si RNA and the target messenger RNA si RNAs often have perfect complementarity to their target sites once bound Argonaut catalyzes cleavage of the messenger RNA which will then be degraded microRNAs also guide risk to messenger RNAs usually only part of a micro RNA known as the seed pairs with a target messenger RNA this imprecise matching allows micro rna’s to target hundreds of endogenous messenger rnas targeting bio micro RNA can lead to messenger RNAs being degraded or translation being inhibited argonauts and their small regulatory RNA cofactors are found in plants animals fungi and some bacteria and their importance in a multitude of biological processes and as tools continues to be revealed you

100 thoughts on “RNA interference (RNAi): by Nature Video

  1. really good video, but it's way too fast, for me at least, I had to check if the video speed hadn't been increased, haha!

  2. This video is amazing! It's so rare that you find a bio animation that has really fancy animations, and also isn't just a rehash of something that's already been done hundreds of times on YouTube before, like DNA replication or something. Thanks for making this so easy to understand!!! 😀

  3. Guys just a question I need help with? Does the siRNA get added onto a existing RNA which is produced during transcription and then exported out of the nucleus?

  4. 0:22 Craig c Mello was awarded the Nobel prize in medicine for the discovery of RNAi in nematode caenorhabditis elegans

  5. This video has to be the best one on Youtube for this topic. It manages to pack in all the correct terminology, clearly and concisely, while being accompanied by fantastic animations. I will definitely be recommending this video to my classmates! Thankyou!

  6. I really like the video graphic animations, but white text with the key terms such as DROSHA/DRGC8/DICER/AGO/RISC/ETC would have been quite helpful.

  7. I would love to be alive in about 100 yrs, or less, to see how this solves some of our medical/pharmaceutical problems. I love science!

  8. I had to turn captions on and pause at every step to digest what is being said. It's difficult to watch the animation and process the information at the same time.

  9. Stunning graphics. I'm currently reading Molecular Biology of the Gene 7 Ed chapter on Regulatory RNAs. Fascinating stuff.

  10. This >>>>>>>>> alien tech and rocket science, finding new dimensions , discovery of wormhole, invention of time machine.

  11. One question pls. The dsRNA which is forming siRNA n miRNA is it produced by the cell's DNA or is it the genetic material of the pathogen??? Pls help. And also how is the stuff in this video different from RNAi being induced by biotechnology as in case of Meloidogyne incognita ?

  12. There is only one comment which I see that is based on reality and the real reason for this manipulation, the rest are a bunch of children which are just loving the animation.
    to the tune of 6.4K when you find yourself in the majority, it may be time to pause…

  13. I'm gonna have to watch this again. I heard nothing the guy was saying the first time through because the animation was so good.

  14. That's how messengerRNAs are fu**ed by siRNA and micro RNA. Sins of DNA and punishment to the RNA.. Not fair. We need CRISPR.

  15. Precisely targeted control! Regulation! These require intelligence to setup. I hope no one tries to explain the origin of the wonders described herein as products of dumb natural processes.

  16. At 3:10 some free roaming enzyme grabs an unneeded strand of RNA and grinds it up into it's constituent nucleotides, apparently for reuse elsewhere. Cool! But whoa! I wonder if they also grind up DNA and proteins. If too many of those things get produced, they could grind up everything and turn the host into a puddle of goo.

  17. An idea: A netflix ~8 episode series touring the interior of a cell, with David Attenborough narrating, with all the same storytelling that goes into Planet Earth.

  18. There is no chance that all this happens randomly.
    I believe in Jesus; by Him and though Him all things were created and hold together.

  19. wow, so amazing, that these self-replicating self organizing self correcting machines all started by a process of chemical natural selection whereby the first proteins formed by chance and by more sheer chance created the first cell membranes, DNA and mitochondria. Just WOW!

  20. I like this video cause it at least attempts to show a bit of the chaos that's taking place in the cell. Every other video makes things look nice and organized and it's super misleading and less interesting that way imo!

  21. How do all these things know precisely where to go and how do they get their energy to maneuver and how do they really maneuver (a muscular system ?) ?

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